Connexin-Based Signalling in Acute Myelogenous Leukemia (AML).
Connexin-Based Signalling in Acute Myelogenous Leukemia (AML).
Biochim Biophys Acta. 2009 Oct 30;
Authors: Foss B, Tronstad KJ, Bruserud O
Normal and malignant hematopoiesis are regulated by intercellular communication in the hematopoietic microenvironments, and both soluble mediators as well as direct cell-cell contact play important functional roles. Gap junctions are complex membrane structures that transfer molecules between neighbouring cells and thereby alter intracellular signalling and metabolism. The gap junction building blocks, the connexins, are also involved in gap junction independent intercellular communication by forming hemichannels that transfer substances between the intra- and extracellular spaces. Connexins are furthermore involved in cell regulation as single molecules by modulating intracellular pathways and possibly gene transcription. The role of connexins in leukemogenesis and leukemic cell functions are not well characterized. In this review we describe the known effects of gap junctions and connexins in acute myelogenous leukemia (AML) and the diverse potential of connexins in AML chemosensitivity, intracellular signalling and cell death regulation.
PMID: 19883623 [PubMed - as supplied by publisher]
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Connexin-Based Signalling in Acute Myelogenous Leukemia (AML).
Connexin-Based Signalling in Acute Myelogenous Leukemia (AML).
Biochim Biophys Acta. 2009 Oct 30;
Authors: Foss B, Tronstad KJ, Bruserud O
Normal and malignant hematopoiesis are regulated by intercellular communication in the hematopoietic microenvironments, and both soluble mediators as well as direct cell-cell contact play important functional roles. Gap junctions are complex membrane structures that transfer molecules between neighbouring cells and thereby alter intracellular signalling and metabolism. The gap junction building blocks, the connexins, are also involved in gap junction independent intercellular communication by forming hemichannels that transfer substances between the intra- and extracellular spaces. Connexins are furthermore involved in cell regulation as single molecules by modulating intracellular pathways and possibly gene transcription. The role of connexins in leukemogenesis and leukemic cell functions are not well characterized. In this review we describe the known effects of gap junctions and connexins in acute myelogenous leukemia (AML) and the diverse potential of connexins in AML chemosensitivity, intracellular signalling and cell death regulation.
PMID: 19883623 [PubMed - as supplied by publisher]
Sponsored Content:
Posted in: Biochim Biophys Acta
This entry was posted
on Wednesday, November 4th, 2009 at 2:56 pm and is filed under Biochim Biophys Acta.
You can follow any responses to this entry through the RSS 2.0 feed.
You can skip to the end and leave a response. Pinging is currently not allowed.
