Isolation of Antagonists of Antigen-Specific Autoimmune T Cell Proliferation.
Isolation of Antagonists of Antigen-Specific Autoimmune T Cell Proliferation.
Chem Biol. 2009 Nov 25;16(11):1133-1139
Authors: Gocke AR, Udugamasooriya DG, Archer CT, Lee J, Kodadek T
Antigen-specific T cells play a major role in mediating the pathogenesis of a variety of autoimmune conditions as well as other diseases. In the context of experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis, we present here a general approach to the discovery of highly specific ligands for autoreactive cells. These ligands are obtained from a combinatorial library of hundreds of thousands of synthetic peptoids that is screened simultaneously against two populations of CD4+ T cells. Peptoids that recognize autoreactive T cells with extremely high specificity can be identified in the library. Since no specific knowledge is required regarding the nature of the native antigens recognized by the autoreactive T cells, this technology provides a powerful tool for the enrichment and inhibition of autoimmune cells in a variety of disease states.
PMID: 19942136 [PubMed - as supplied by publisher]
Sponsored Content:
This entry was posted on Saturday, November 28th, 2009 at 11:59 pm and is filed under Chem Biol. You can follow any responses to this entry through the RSS 2.0 feed. You can skip to the end and leave a response. Pinging is currently not allowed.
