[FLT3 mutation in patients with acute lymphoblastic leukemia and its clinical significance]
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[FLT3 mutation in patients with acute lymphoblastic leukemia and its clinical significance]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009 Oct;31(5):522-6
Authors: Zhao X, Tang KJ, Tian Z, Chen LP, Mi YC, Wang JX
OBJECTIVE: To investigate fms-like tyrosine kinase 3 (FLT3) mutation in patients with acute lymphoblastic leukemia (ALL) and its clinical significance. METHODS: FLT3 mutation-internal tandem duplication (FLT3-ITD) and FLT3 mutation in the tyrosine kinase domain (FLT3-TKD) were detected using polymerase chain reaction (PCR) in the genomic DNA of 61 ALL patients and 7 healthy volunteers (as reference group). The PCR products of these patients who were detected with FLT3-ITD or FLT3-TKD were sent for sequence analysis. RESULTS: In all these 61 ALL patients, FLT3-ITDs were identified in 2 patients and FLT3-TKD were identified in one patient. CONCLUSION: FLT3-ITD and FLT3-TKD exist in a small proportion of ALL patients.
PMID: 19968062 [PubMed - in process]
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