Ghrelin as a Novel Therapy for Radiation Combined Injury.
| Related Articles |
Ghrelin as a Novel Therapy for Radiation Combined Injury.
Mol Med. 2010 Jan 24;
Authors: Jacob A, Shah KG, Wu R, Wang P
There is a growing concern in the world about the exposure to radiation due to the threat of nuclear terrorism. Acute radiation syndrome or radiation sickness develops after a whole body or a partial body irradiation with a high dose of radiation. In the terrorist radiation exposure scenario, however, radiation victims likely suffer from additional injuries such as trauma, burn, wound, or sepsis. This concern has resulted in the need to study whole-body radiation related injuries to intervene therapeutically if such need arises. Despite advances of our understanding of the pathophysiology of radiation injury, very little information is available on the therapeutic approaches of radiation combined injury. In this review, we describe briefly the pathological consequences of ionizing radiation and provide an overview of the animal models of radiation combined injury. We highlight the combined radiation and sepsis model we recently established and suggest the use of ghrelin, a novel gastrointestinal hormone, as a potential therapy for radiation combined injury.
PMID: 20101281 [PubMed - as supplied by publisher]
Sponsored Content:
This entry was posted on Wednesday, January 27th, 2010 at 7:31 am and is filed under Mol Med. You can follow any responses to this entry through the RSS 2.0 feed. You can skip to the end and leave a response. Pinging is currently not allowed.
